This is an incredibly tough event to define a boat for. It really depends on what happens with wind, sea state and weather. What is a great choice on year would probably be a loser the next. What can win on leg isn't going to be fastest in other legs.
It really depends on what segment of the race you choose as your design focus as well. Crossing the Gulf far offshore (in possibly bad weather) defines a very different boat than noodling through shallow draft swamp canals and across obstacles & weed.
The one common thread I've noticed on winning boats is that they are light, fast, 18-20 foot plus long and minimise the exposure time on the worst segments. Hence the speed domination of the multihulls, and the two handed boats where headway is made while one crew is resting.
The beach launch criteria really shortens the list, but if Meade and Jan Goudgeon can drag an i550 down the beach, there are still lots of possibilities.
If we are talking monohulls, Graham Byrnes EC22 is still very much a good balance of speed plus the capacity to handle rough offshore worst case conditions. The small cuddy and bunk, plus a porta potty means a two man crew can keep going the 48-36 hours non-stop needed. No concession to fixed ballast and unneeded weight is made, and with a big asym, downwind planing is very possible. The cat/ketch rig has lots of possible configurations and can adapt to a range of conditions.
If conditions were perfect, a sloop rigged boat with higher aspect ratio main would have a higher top end speed potential, and the much taller mast would allow a lot more downwind sail area from an asymmetrical spinnaker/reacher. The taller rig would mean a whole lot more trouble sneaking under bridges though.
I love this event and follow it every year from afar - wishing I could one day be involved.
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CutOnce