You should either select better information sources or make sure you understand the basic concepts beforehand.
Epoxy isn't going to let damp air in and rot the ply, that's in the same tales category as "wood breathing". Every foam that's used as a structural core in boat building is closed cell and doesn't absorb water like a sponge, regardless of its chemistry.
Using a high density foam like Thermo-Lite for the entire hull is only necessary for special cases, and a cruising sailboat isn't one. You could legitimately use it in a few places, but that would be maybe a few square feet for the entire boat.
If you don't like or trust plywood and epoxy just buy plans designed for foam. Do yourself a favor, compare the price and weight of regular boatbuilding foam (PVC, SAN, PET) to this stuff. If you want to compare apples to apples you need to compare the weight and cost of the entire layup, from outside paint to inside paint, but that's only possible if the design already has several build options. Otherwise you can only look at similar size and displacement boats, but the designers don't necessarily have the same priorities, so at times the results can be somewhat strange.
One thing to keep in mind is that the golden age of big plywood builds has passed. Not because plywood was found to be an inferior material but because cost has increased and closed the gap to other materials even for the amateur builder.
Here's a reality check: you can find perfectly fine 50 year old boats made from polyester-balsa, polyester-PVC foam, epoxy-plywood, epoxy-wood, and some other techniques that aren't in use anymore. At the same time you can find 10 year old boats of the same construction that are basically shot because they were improperly buildt or maintained.