We are lucky to pull out 35 pcs on a mold made of poly before repairs (to the mold) start to become necessary. It is the cyclic heat of part curing that damages it plus the tapping of mallet to release deep drawn parts. However, we have used a good quality, high temperature tooling mold resin that lasted up to 350 parts (simple low curvature panels) before it showed signs of fatigue.
The flange are for alignment purposes only and a means to initiate part release. 3 to 4" will do. It should also stiffen the mold when external mold stiffeners/frames are added in.
Thickness? Manual says it should not be thicker than the part to be made/ I make mine 20% thicker or enough to make it stiff.