The mechanical properties of HDPE are very different from those of Aluminum. Here are some numbers:
HDPE:
yield stress: sigma,y = 22 MPa
elastic modulus: E = 860 MPa
Aluminum 5086-O:
yield stress: sigma,y = 170 MPa
elastic modulus: E = 71000 MPa
These numbers can give you a base for comparison of structures made with these two material. Take a case of two simple flat plates subject to bending moments (due to hydrostatic pressure acting on its surface, for example). Let's assume that the external pressure is the same for both plates, and that the only thing in which the two plates differ is their thickness.
Let's call them plate A and plate B. The plate A is made of HDPE, the plate B is made of aluminum.
I will save you from the math, which can be checked in any text book about structural engineering, and will jump directly to the results.
If you want to make the plates A and B work inside the same factor of safety for a given external load, the plate A (HDPE) will have to be 2.5 times thicker than the plate B (aluminum).
However, since the rigidity of HDPE (expressed throught the quantity E) is 83 times lower than aluminum's, the plate A will flex much more than the plate B, for the same thickness. In other words, if the aluminum plate B flexes .1 mm under a given load, the HDPE plate A will flex around 4 mm - which is a very big number.
Hence, in order to keep the hull flexing in a reasonable range, the HDPE boat will require much denser internal framing than the original aluminum boat.
You can also keep the same frames spacing, but then you will have to increase the thickness of the HDPE plate. Precisely, in order to keep the same deflection of the two plates under a given external load, the HDPE plate needs to be 4.5 times thicker than an aluminum plate.
So, if the original project calls for 5 mm thick aluminum plate, the HDPE replacement will have to be roughly 22 mm thick. If the idea behind the project was a weight saving by replacing the aluminum with HDPE, these numbers tell you that the end result might be very disappointing.
Of course, these numbers serve just to give you a ballpark figure. As you can understand by looking at these figures, you are embarking into something that goes well beyond a mere replacement of the hull material. The corresponding change in thickness of all structural members will require a thorough re-thinking of the whole design.
Advice: get a help from a professional boat designer or from a structural engineer.
Cheers